JCS -- Kitajiri et al. 117 (21): 5087 Figure IG7

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Fig. 7. Potassium concentration and endocochlear potential (EP) of endolymph. (A) The method for recording the potassium potential (PP) and EP. A double-barreled K⁺-selective microelectrode is directly inserted into the scala media of the basal turn of the cochlea of 10-week-old mice under anesthetic. (B) Recordings of PP and EP of endolymph in Cld11^+/+ and Cld11^-/- cochlea. Cld11^+/+ and Cld11^-/- cochlea showed similar PPs ( $~$ 70 mV), indicating that endolymph of both Cld11^+/+ and Cld11^-/- cochlea contained similar K⁺ concentrations [Cld11^+/+, 148±7 mM (n=6); Cld11^-/-, 145±6 mM (n=6)]. By contrast, the EP of Cld11^-/- cochlea [31±14 mV (n=6)] is significantly lower than that of Cld11^+/+ cochlea [95±6 mV (n=6)].