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Fig. 2. Conserved domains in AMPK subunits: (A) {alpha} subunits, (B) ß subunits and (C) {gamma} subunits. The proposed function of each domain is indicated. The two isoforms of the {alpha} ({alpha}1, {alpha}2) and ß (ß1, ß2) subunits have very similar structures, but the three isoforms of the {gamma} subunit ({gamma}1, {gamma}2, {gamma}3) contain variable N-terminal regions of unknown function, and are drawn separately. [Redrawn from Hardie et al. (Hardie et al., 2003).]