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Fig. 5. PHI-1 depletion by siRNAs accelerates HUVEC spreading. (A) HUVEC knocked down for PHI-1 exhibited a 13% larger surface area after 30 minutes than control cells (*P<0.05, n=30). (B) Kinetics of cell spreading for a control (squares) vs a PHI-1 knockdown HUVEC. The slopes of the lines represent the rate of cell spreading. (C) Rate of cell spreading of control vs PHI-1 knocked-down HUVECs (*P<0.05, n=3).