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Fig. 4. Importin-ß localization to asters/spindle poles depends on MT integrity and dynamics. (A) IF analysis of importin-ß/FITC and {gamma}-tubulin/rhodamine in mitotic cells released from thymidine arrest and exposed to NOC or TAX, or after NOC release. (B) Frequency of mitotic figures in which importin ß did or did not localize to asters/spindle poles in the presence of MT-directed drugs. 200 mitoses per condition were analyzed in four experiments.