Fig. 1. Primary structure of the mouse tenascin-W protein. (A) Mouse tenascin-W amino acid sequence translated from the DNA database entry (accession number AJ580920). The signal peptide is underlined (dashed). Amino acids 99-132 represent the heptad repeats flanked by cysteines, amino acids 155-259 the EGF repeats, amino acids 260-1056 the FNIII repeats and amino acids 1057-1296 the fibrinogen globe. The RGD sequence in the second FNIII repeat is boxed (grey), the IDG motifs are double underlined and BBXB sites are underlined. (B) Relationship between FNIII repeats created by the program pileup of the GCG software package. (C) Schematic representation of the domain structure of mouse and zebrafish tenascin-W depicting an N-terminal domain (wedge), heptad repeats (wavy line), EGF-like repeats (diamonds), FNIII repeats (squares; central highly similar repeats shaded in black) and fibrinogen globe (circle). Homologous FNIII repeats between mouse and zebrafish tenascin-W are interconnected by dashed lines.