Fig. 1. Alignment of integrin cytoplasmic tails. The amino acid sequences of human tails and Drosophila PS1 and Caenorhabditis elegans PAT2 (A), and human ß and Drosophila ßPS and C. elegans ßPAT3 (B) were manually aligned. The divergent human ß4 and ß8 and alternative splice variants of 3, 6, ß1 and ß3 were omitted. The interface between the transmembrane and cytoplasmic regions is generally assumed to lie between the conserved W/Y and K residues, shown in bold. The conserved membrane-proximal subunit GFFKR and ß subunit LLxxxHDREE are shown in red. The conserved ß tail residues involved in talin binding are indicated; the first, ß turn-forming, NPxY motif is shown in blue and the conserved tryptophan is shown in pink.