Fig. 6. Loss of costameric lattice in dy^2J fibers with central and peripheral nuclei. Confocal images of teased muscle fibers from an 11-week-old dy^2J dystrophic mouse stained with DAPI (blue) to detect nuclei and with IIH6 antibody (red) to detect -dystroglycan. Cross-sectional views (a,b; d,e) reconstructed from serial optical 0.5 µm sections taken approximately at positions indicated by yellow lines in en face views of upper surface (c,f). Red vertical lines indicate lateral borders of fiber in c. Note dystrophic pattern seen in myofiber containing central nuclei (a-c) and peripheral nuclei (d-f).