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Fig. 1. Amino acid sequence of chick lens MIP(AQP0). (A) Sequence of cDNA clone of MIP(AQP0). A single uninterrupted open reading frame starting at nucleotide 67 and ending at nucleotide 885 (bold, underline), encoding a protein with a predicted molecular mass of 28.1 kDa. The derived amino acid sequence of MIP(AQP0) is shown in lower line. This sequence is registered in the GenBank database under the accession number AY078179. (B) The deduced amino acid sequence of chick MIP(AQP0) in one-letter code is aligned to the bovine lens MIP(AQP0) (K02818). Identical residues are shaded. Putative membrane-spanning domains (TM) are labeled and underlined.