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Fig. 3. Neoplasms developed in NMU-treated stroma only. (A) Mammary gland whole-mount preparations show abnormal outgrowths in animals whose cleared fat pads were exposed to NMU prior to recombination with vehicle-treated mammary epithelial cells (Group 1) or NMU-treated mammary epithelial cells (Group 2). Neoplastic lesions (arrows) were confirmed histologically. Groups 3 and 4 developed normal-like ductal outgrowths. Bar, 2 mm. (B) Percentage of neoplastic lesions and incidence of carcinomas per experimental group. The number of rats with neoplastic lesions out of the total number of animals in each group is indicated in parenthesis. *See Materials and Methods for further details.