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Fig. 7. {Delta}Ext/R4Tth-induced intranuclear membranous structures. COS cells expressing R4wt (A) or {Delta}Ext/R4Tth (B-F) were labeled with antibody against FGFR4 followed by protein-A/gold. (A) R4wt localized mainly to the outer membrane of the NE. (B) {Delta}Ext/R4Tth localized to the NE. Labeling of both the INM and ONM can be seen. (C-F) {Delta}Ext/R4Tth was found in the nucleus in onion-like membrane structures. (F) is a magnification of the central region of the image in E). Nu, nucleus. Scale bars, 200 nm.