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Fig. 5. Model of MMP-9 induction in fibroblasts by breast-cancer cells. Tumor-cell-derived TGF-ß and TNF- directly induce expression of MMP-9, which is augmented indirectly by the effects of these cytokines on HGF- and EGF-signaling.
directly induce expression of MMP-9, which is augmented indirectly by the effects of these cytokines on HGF- and EGF-signaling.