Fig. 8. Accumulation of aberrant multivesicular structures in tGolgin-1-depleted cells. HeLa cells transduced twice with siRNA-1 were fixed 1 day later and processed for conventional electron microscopic analysis. Typical fields are shown from these cells containing aberrant vacuolar structures (*), which appear to be derived from multilaminar (A,B) or multivesicular (C) endosomes. Notice the peripheral Golgi mini stack (G) in A. m, mitochondria; n, nucleus. Bar, 1 µm.