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Fig. 1. Schematic diagram of the domain structure of KIF13B and its deduced amino acid sequence. (A) KIF13B contains an N-terminal motor domain (aa 56-354), a middle stalk domain and a C-terminal CAP-GLY domain (aa 1661-1703). Amino acid residues are numbered from the first Met of KIF13B. KIF13B{Delta} (aa 387-649) represents the cDNA clone isolated by two-hybrid screening. KIF13B{Delta}C (aa 1-998) was used to study the interaction between KIF13B and centaurin-{alpha}1 in vitro. KIF13B{Delta}MD (aa 355-1767) and KIF13B{Delta}CG (aa 1-1660) were used to study the importance of the motor domain and the CAP-GLY domain for the intracellular localization of KIF13B. (B) Predicted amino acid sequence of KIF13B (GenBank/EMBL/DDBJ accession number AJ605719) is shown. The motor domain, KIF13B{Delta} sequence and the CAP-GLY are underlined with dashed line, solid line and double solid line, respectively.