JCS -- Iserentant et al. 118 (11): 2519 Figure IG10

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Fig. 10. Molecular models of mouse LR CRH2. (A) CRH2 residues that become buried in the leptin/CRH2 interface, coloured according to the area that becomes buried (cyan, <25 Å²; blue, 25-50 Å²; green, >50 Å²). (B) CRH2 residues that lead to a drastic increase of leptin binding to CRH2 and LR activation upon mutation.