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Fig. 5. Tyr372 is essential for function. Typical inward currents elicited by application of ATP (100 µM) at untagged P2X4 receptors and related mutants (Y372A, Y372F, Y378A) expressed in HEK293 cells. Y372F is functional, but Y372A is not. Note the large response of Y378A mutant, reflecting the abundant surface distribution.