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Fig. 1. Structure of AQP1 monomers and their tetrameric assembly in membranes. (A) Crystal structure of AQP1 monomer showing tilted transmembrane {alpha}-helical domains (numbered 1-6) surrounding a water pore. Conserved `NPA' motifs are indicated. (B) Tetrameric assembly of AQP1 in a membrane in which individual monomers contain water pores.