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Fig. 5. Reduced skin hydration in AQP3 deficiency. (A) Schematic showing stratum corneum and epidermal layers. (B) Immunofluorescence showing AQP3 (in yellow) in the basal layer of epidermal cells in mice. E, epidermis; D, dermis; sc, stratum corneum. (C) Proposed mechanism of AQP3 function in skin, showing reduced steady-state glycerol content in epidermis and stratum corneum following AQP3 deletion.