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Fig. 6. Progressive fat accumulation and adipocyte hypertrophy in AQP7 deficiency. (A) Histology of gonadal white adipose tissue in AQP7-null mice at age 16 weeks, showing marked adipocyte hypertrophy. (B) Proposed mechanism for adipocyte hypertrophy in AQP7 deficiency, in which impaired AQP7-dependent glycerol escape results in intracellular glycerol accumulation and increased triglyceride (TG) content. FFA, free fatty acid.