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Fig. 2. Rescue of the ctsl-/- skin phenotype by keratinocyte-specific re-expression of CTSL. (A-C) Immunohistochemical detection of the proliferation marker Ki67 in basal keratinocytes (brown staining; bars 20 µm). (D) Quantitative analysis of epidermal thickness of mouse back skin (Axiovision; Zeiss). (E) Ki67 proliferation index (%) calculated as Ki67-positive basal layer cells divided by total basal layer cellsx100. ***P<0.001 compared with all other groups (n=3, four paraffin sections per mouse). (F,G) Rescue of the periodic hair loss of CTSL-deficient mice in Tg(K14-CTSL);ctsl-/- mice photographed 30 days after birth.