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Fig. 7. A model for the role of Mstn in skeletal muscle healing. Myotrauma activates SCs and the inflammatory response. As a result, macrophages and SCs migrate to the site of injury. Mstn negatively regulates SC activation and inhibits migration of macrophages and SCs. Activated SCs proliferate at the site of injury and resulting myoblasts (MB) either fuse with the damaged myofiber or form a new myotube.