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Fig. 6. Abl regulates PDGF-induced JNK and Nox activation. (A) Abl regulates PDGF-induced JNK activation. (Top panels) The level of active MAPK (pMAPK) and JNK (pJNK) from cells stimulated with PDGF (0-30 minutes). The level of MAPKs and JNK1 is also shown. (Bottom panels) The level of Jun and pS63-Jun (pJun) from indicated cell-lysates. (B,C) Abl regulates PDGF-induced Noxo2 (p47phox) membrane translocation. (B) Immunofluorescence localization of p47phox-GFP, actin structure and nuclei from indicated cells stimulated or not with PDGF as shown. (C) Statistic analysis of p47 membrane recruitment upon PDGF stimulation. Indicated quiescent cells transfected with p47phox-GFP were stimulated with PDGF for 5 minutes and the percentage of cells with p47 membrane localization was counted. The mean±s.d. (n=5) of the percentage of cells that exhibited p47-GFP at the membrane is shown.