Fig. 10. Schematic representation of two potential mechanical linkages between the contractile apparatus and the sarcolemma. The C-terminal region of filamin-C (FLN-C, represented as tail-to-tail associated dimer) binds to the ß1 integrin cytoplasmic domain and both and sarcoglycans associated with the dystroglycan complex at the sarcolemma. The N-terminal region of FLN-C contains an actin-binding domain, which may associate with both sarcomeric actin filaments and cortical actin in the sub-sarcolemmal region, serving thus as a nexus between actin filaments and costameric sites. A number of Z-disc proteins are depicted. Myotilin represented hypothetically as an antiparallel dimer can bind to FATZ-1, FLN-C and -actinin 2 (ACTN2). FATZ-1 can also bind to myotilin, FLN-C and ACTN2. It should be noted that in some cases, where there is more than one protein partner, competition and/or simultaneous binding could occur. Furthermore, it is likely that certain interactions occur only at distinct stages of development.