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Fig. 2. The interrelationship between traction stress, cell shape and speed during one cycle of feedback. (A) An example of a single cycle of mechano-chemical feedback showing relative changes in traction stress (red), cell speed (green), shape factor (orange) and calcium indicator fluorescence (blue). Retraction of the rear cell margin is indicated (R). (B) The average relative changes in traction stress (black bar), cell speed (open bar) and shape (gray bar), associated with eight individual transients, for each phase of the feedback cycle. These are designated the pre-transient (1), transduction (2) and post-transient phases (3) and are also indicated in A.* indicates a significant difference (P<0.05) from pre-transient and transduction measures. {ddagger}indicates a significant difference (P<0.05) from measures of traction stress in all other phases.