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Fig. 5. Immunostaining for human Cripto-1 in mammary glands of MMTV/CR-1 transgenic mice. Increased expression of E-cadherin and UNC5H1 is observed in MMTV/CR-1 mammary glands containing Netrin-1-releasing pellets relative to expression in the control. Peripheral staining for UNC5H1 in the terminal end buds of MMTV/CR-1 control mammary gland was detected compared to staining of the entire terminal end bud in MMTV/CR-1 mammary glands containing the Netrin-1 pellets. Reduced intensity of immunostaining of P-Akt in the epithelial structures, and almost no staining of the stromal component was detected in MMTV/CR-1 mammary glands containing Netrin-1 pellets compared to the strong staining for P-Akt detected in both epithelial and stromal components of MMTV/CR-1 mammary glands implanted with control pellets. Magnification, 40x.