(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 1. MT1-MMP-positive vesicles in MCF-MT-WT cells. Two hours after Chariot delivery of the MT1-MMP antibody Ab815 (left panels) and 1 hour after the Ab815 uptake (middle and right panels), the cells were fixed, permeabilized and stained for {alpha}-tubulin (red) and Ab815 (green). Where indicated, the cells were pre-treated for 1 hour with nocodazole (1 µg/ml). Enlarged areas (boxed in top panels) show the MT1-MMP-positive vesicles (indicated by arrows) localized alongside the microtubule cytoskeleton. DAPI nuclear staining is blue.