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Fig. 7. Role of Mec1 in restricting chromosome reorganization in set1{Delta} cells. Frequencies of nuclei displaying a single centromere FISH signal (% cen cluster), two to eight perinuclear telomere FISH signals (% tel cluster) or a single telomere FISH signal cluster (% bouquet) in wild-type and set1{Delta} mec1-1 strains, at the indicated time points after transfer into sporulation medium. Top: wild-type and set1{Delta} mec1-1 FACS profiles aligned to the corresponding time points.