Fig. 6. Modulation of CBP expression alters proliferation in rECM culture. (A-D) Inhibition of CBP expression in HMECs by antisense ODNs results in enhanced proliferation in rECM. Ki-67 staining indices (A,C) in early passage HMEC-LXSN cells (passage 11) (A) and early passage HMEC-E6 cells (passage 11) (C). The mean number of nuclei per cell cluster (B,D) in early passage HMEC-LXSN vector controls (passage 10) (B) and early passage HMEC-E6 cells (passage 11) (D) treated with either CBP antisense ODN (A3342V; CBP AS) or inactive CBP ODN (scrA3342V; CBP scr). Two hundred cells were surveyed per time point and indices were calculated from an average of three independent experiments. Error bars show standard error.