Fig. 2. Aberrant development in Cx43-deficient ovaries is due to defects in granulosa cells, not oocytes. (A) A 43^–/–oo/43^+/+gc ovary containing follicles at all developmental stages, including antral stages. (B) A 43^+/+oo/43^–/–gc ovary at the same magnification as (A) showing a preponderance of small follicles at the primary and early secondary follicle stages. The graphs show mean oocyte (C) and follicle (D) diameters across chimeric ovary combinations. Bars with different letters above them are significantly different (P<0.01). The numbers in parentheses indicate the numbers of oocytes or follicles measured. Bar, 50 µm.