Fig. 3. Function of paracellin-1. (A) Effects of paracellin-1 on the permeability of Na+ and Cl- in LLC-PK1 cells. (B) Ratio of PNa to PCl and diffusion potential (bottom) across a LLC-PK1 cell monolayer. (C) TER across an LLC-PK1 cell monolayer over a period of 12 days in cells expressing paracellin-1 and control cells. (D) Summary of the effects of paracellin-1 upon permeability of various cations in LLC-PK1 cells.