(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 6. Model for the dimerization of gp130 and LIFR. According to our data, a large portion of gp130 exists as a transient homodimer in the plasma membrane (a). This preformed homodimer is stabilized upon binding of IL-6/IL-6R{alpha} complexes (b). Monomeric gp130 binds IL-6/IL-6R{alpha} complexes less efficiently (c) and therefore only marginally contributes to IL-6-signalling. A gp130/LIFR heterodimer is formed mainly in response to LIF stimulation (d).