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Fig. 4. Effects of FK506 on IP3-evoked Ca2+ increases in voltage-clamped single colonic myocytes. Photolysed caged IP3 ({uparrow}) significantly increased [Ca2+]c as indicated by F/F0. FK506 (10 µM, n=11, P<0.05) potentiated the IP3-evoked [Ca2+]c transients.