JCS -- MacMillan et al. 118 (23): 5443 Figure IG5

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Fig. 5. Effects of the calcineurin inhibitors cypermethrin and okadaic acid on IP₃-evoked Ca²⁺ increases in voltage-clamped single colonic myocytes. Photolysed caged IP₃ ( ${uparrow}$ ) increased [Ca²⁺]_c as indicated by F/F₀. The IP₃-evoked [Ca²⁺]_c transient was significantly increased by each inhibitor. (A) Cypermethrin 10 µM, n=12, P<0.001; (B) okadaic acid 5 µM, n=8, P<0.05.