Fig. 6. Effect of FK506 on IP₃-evoked Ca²⁺ increases following calcineurin inhibition in voltage-clamped single colonic myocytes. Following pre-treatment with the calcineurin inhibitors (A) CiP (100 µM), (B) okadaic acid (5 µM) or (C) cypermethrin (10 µM), FK506 (10 µM) did not increase the IP₃-evoked [Ca²⁺]_c transient produced by photolysed caged IP₃ () as it had done in the absence of inhibitors (cf. Fig. 4).