Fig. 1. Migfilin and its binding partners. The figure depicts migfilin domain structure, splicing variants and its binding partners. Double arrows represent direct interactions of migfilin with filamin A, B or C (mediated by the N-terminal domain of migfilin and the 21st repeat of filamin A/C (Tu et al., 2003) or the 10-13th repeats of filamin B (Takafuta et al., 2003], VASP (mediated by the central proline-rich domain of migfilin and the EVH1 domain of VASP) (Y. Zhang, Y. Tu and C.W., unpublished data), CSX/NKX2-5 (mediated by the C-terminal LIM region of migfilin and the homeodomain of CSX/NKX2-5) (Akazawa et al., 2004) and Mig-2 (mediated by the C-terminal LIM region of migfilin) (Tu et al., 2003).