Fig. 1. Domain structure of the major nesprin-2 isoforms identified to date. Isoforms lacking the transmembrane/KLS domain are designated TM. The size of the mRNA in kb is shown as well as the predicted molecular mass in kDa for each isoform. Regions shown in green are predicted to form a continuous rod domain in the presence or absence of amino acids encoded by the small alternatively spliced exons shown in green with an asterisk in Fig. 2.