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Fig. 12. Nesprin-2 epitopes are present in the sarcoplasmic reticulum in human skeletal muscle. Punctate Nesprin-2 N3 epitopes co-localize in a punctate fashion with RyR, a junctional SR marker (A-C). Larger areas of co-localization are apparent with both N3 and CH3 (not shown) and SERCA2, a free SR marker, in longitudinal sections (D-F) and confirmed in cross sections (G-I). Bar, 4 µm.