Fig. 4. Epitope mapping of antibody GC4. (a) Binding of mAb GC4 to dimeric N-cadherin Fc bearing point mutations, in the presence of 1.25 mM calcium. (b) Amino acids K64, P65, D67 and Q70 (purple) are seen in relation to the position of non-intercalated Trp2 (blue) and the ßA strand (orange).