Fig. 6. Modelling the formation of `reporter' disulphide bonds formed during strand exchange in domain 1. Structures are derived from PDB 1NCI (Shapiro et al., 1995). The two opposing N-cadherin domains are shown in pale blue and brown respectively. The side chain of Trp2 (brown) is shown located in the hydrophobic pocket of the blue domain. (a) The backbone of C1 is shown in red and the side chain forms a disulphide bond (yellow) with C27 (dark blue). (b) The disulphide bond is formed between C1 (red) and C25 (dark blue).