Fig. 2. Development of the immediate transcript environment. (A) The viral genome enters the nucleus. (B) The viral genome is then deposited between a PML body and an SC35 domain, and early transcripts are produced. (C) IE72 is then translated and localizes to the PML body, whereas IE86 is localized between the PML body and SC35 domain. (D) The PML body is disrupted by IE72. (E) The viral transcripts are processed in the SC35 domain. (F) The mature viral transcripts leave the SC35 domain. Adapted from (Ishov et al., 1997).