Fig. 2. The majority of RGC axons in Bcl-2tg mice regenerate and reach the ipsilateral brain targets within 4 days. (A-F) Epifluorescence photomicrographs of coronal brain sections from a Bcl-2tg mouse on day 4. Note green fluorescence (CTB) in the ipsilateral SC, pretectal nuclei (PT) (A), dorsal (dLGN) and ventral LGN (vLGN) (B), and the optic tract (C). Weak fluorescence is present in the corresponding contralateral targets (D-F). Dotted lines outline the SC and dLGN. Arrows indicate regenerating axons showing positive fluorescence in the optic tract. Bar, 200 µm. (G,H) Schematic drawings of CTB-labeled retinofugal projections in coronal sections of mouse brain. (G) Retinofugal projection formed by regenerating axons in Bcl-2tg mice. (H) Retinofugal projections in normal wt and Bcl-2tg mice. No apparent abnormality of retinal axon projection is noted in uninjured Bcl-2tg mice compared with wt controls.