Fig. 6. FGF-2-induces tyrosine phosphorylation of p190RhoGAP, which is inhibited by PEDF. IBE cells or KDFyn-8 cells were cultured on Matrigel in the presence or absence of 20 ng ml^–1 FGF-2 with or without 200 ng ml^–1 PEDF for 2 hours. Cells were washed and lysed, and p190RhoGAP was immunoprecipitated. Tyrosine phosphorylation was examined by immunoblotting.