JCS -- Turvey et al. 118 (5): 971 Figure IG7

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Fig. 7. Inhibitory effects of latrunculin B on Ca²⁺-dependent Cl^– current spikes are mediated by an inhibition of the underlying local Ca²⁺ signal. Latrunculin B inhibits Ca²⁺-dependent Cl^– current spikes induced by (2,4,5)IP₃ in whole-cell patch-clamped pancreatic acinar cells (A). At time points i-v shown in the patch-clamp trace the average Ca²⁺ signal, denoted by an asterisk and measured within the white box shown in the phase image, was measured (B). The pseudocolour fluorescence ratio image at these times is also shown.