Fig. 1. E-like, a protein related to tubulin-folding cofactor E. (A) Amino acid sequence comparison showing 23% identity between human E-like (El) and cofactor E (Cof E). (B) Evolutionary relationship between currently known cofactor E-related sequences; fly, Drosophila melanogaster; celeg, Caenorhabditis elegans; atha, Arabidopsis thaliana; yeast, Saccharomyces cerevisiae; spombe, Schizosaccharomyces pombe; leisch, Leishmania donovani. (C) Schematic of domains identified in cofactor E and E-like. CAP-gly, glycine-rich cytoskeleton-associated protein domain; LRR, leucine-rich repeat sequence; UBL, ubiquitin-like domain. (D) Northern blot showing distribution of E-like expression in various human tissues. Location of size markers is indicated on the left.