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Fig. 6. Inhibition of ERK1/2 signalling enhances ERK5 activation by Src. NIH3T3 cells were transfected with expression vectors for Y527F Src, dominant-negative MEK1 (MEK1A), dominant-negative MEK5 (MEK5AA) or ERK5 (ERK5AEF), where indicated, cells were treated with 1 µM PD184352 (PD1) or 10 µM (PD10) for 24 hours.