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Fig. 12. Proposed model showing that targeting of NHE7 from the recycling endosome to the TGN is facilitated by binding to SCAMPs. Expression of the SCAMP2/{Delta}184-208 mutant blocks the normal targeting by interfering with full-length SCAMP, whereas GFP-tagged SCAMP2 TM2-TM3 (GFP-TM2-3) blocks normal targeting of NHE7 by competitive inhibition with endogenous SCAMPs. EE, early endosomes; RE, recycling endosomes; PM, plasma membrane; TGN, trans-Golgi network.