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Fig. 5. The Kir2.1 Golgi-to-plasma membrane trafficking signal governs surface expression of Kir2.1/Kir2.4 heteromers. (A) Co-expression of GFPKir2.1 increases surface expression of HA-tagged Kir2.4. (B) Co-expression of Kir2.1 with the identified trafficking signal having been replaced by the homologous Kir2.4 sequence [Kir2.1-int(2.4)] reverses the effects of co-expressed wild-type GFPKir2.1 on promoting surface expression of HA-tagged Kir2.4. *Statistically significant when compared with respective control (P<0.01; unpaired Student's t-test; see Materials and Methods).