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Fig. 1. Immunohistochemical staining of K8+/+ and K8–/– colons with fluorescent antibodies to T cell surface markers; the original color staining is depicted in black and white. Frozen sections from 6-month-old K8+/+ and K8–/– colons were triple-stained with fluorophore-conjugated antibodies directed to: CD8 (PE, red), CD4 (FITC, green), and TCRß (APC, blue). A dramatic increase in the number of TCRß and CD4+ cells are present within the LP and mucosa of the K8–/– (d-f) as compared to the K8+/+ (a-c) colons. L, lumen; M, muscle layer. Scale bar: 50 µm.