Fig. 1. Western-blot analysis of CPA and pro-CPA in peritoneal cells from cathepsin-deficient mice. Peritoneal-cell extracts from mice deficient in cathepsin B (A), cathepsin L (B), cathepsin D (C) or cathepsin E (D), and extracts from corresponding wild-type or heterozygous mice, were subjected to western-blot analysis using a an antiserum that recognizes both pro-CPA (55 kDa) and processed CPA (35 kDa). Cat, cathepsin.