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Fig. 6. Ca2+-induced Ca2+ release in WT and PERK-/- urinary bladder smooth muscle strips. Changes in [Ca2+]i (A) and force (C) in UBSM strips from WT (upper traces in each set) and PERK-/- mice (lower traces in each set) depolarized with 20-80 mM K+. The average [Ca2+]i and force increases in three WT ({blacksquare}) and three PERK-/- ({circ}) mice are summarized in B and D, respectively and are given as the mean ± s.e.m. The responses were calculated as a percentage of those induced by 80 mM KCl in each strip.