Fig. 11. Cholesterol and CD81 are functionally linked during Plasmodium sporozoite invasion. HepG2 (A) or HepG2/CD81 cells (B,C) were treated with MßCD followed by MßCD/cholesterol when indicated before infection by P. berghei (A,C) or P. yoelii (B) sporozoites. The number of exo-erythrocytic form (EEF)-infected cells was determined as described in the Materials and Methods section. **P<0.01, as compared to untreated control.